Hydroxylated aromatic inhibitors of HIV-1 integrase

…, AM Carothers, D Grunberger, J Driscoll…

Index: Burke Jr.; Fesen; Mazumder; Wang; Carothers; Grunberger; Driscoll; Kohn; Pommier Journal of Medicinal Chemistry, 1995 , vol. 38, # 21 p. 4171 - 4178

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Citation Number: 208

Abstract

Efficient replication of HIV-1 requires integration of a DNA copy of the viral genome into a chromosome of the host cell. Integration is catalyzed by the viral integrase, and we have previously reported that phenolic moieties in compounds such as flavones, caffeic acid phenethyl ester (CAPE, 2), and curcumin confer inhibitory activity against HIV-1 integrase. We now extend these findings by performing a comprehensive structure-activity ...

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