Design, synthesis, biological evaluation and docking studies of pterostilbene analogs inside PPARα

…, G Ma, S Khan, A Patny, MA Avery, AM Rimando

Index: Mizuno, Cassia S.; Ma, Guoyi; Khan, Shabana; Patny, Akshay; Avery, Mitchell A.; Rimando, Agnes M. Bioorganic and Medicinal Chemistry, 2008 , vol. 16, # 7 p. 3800 - 3808

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Citation Number: 52

Abstract

Pterostilbene, a naturally occurring analog of resveratrol, has previously shown PPARα activation in H4IIEC3 cells and was found to decrease cholesterol levels in animals. In this study, analogs of pterostilbene were synthesized and their ability to activate PPARα was investigated. Among analogs that was synthesized (E)-4-(3, 5-dimethoxystyryl) phenyl dihydrogen phosphate showed activity higher than pterostilbene and control drug ...