Metalation reactions. XVI. Polylithiation of 1, 3, 5-and 1, 2, 4-trimethoxybenzene

S Cabiddu, L Contini, C Fattuoni, C Floris, G Gelli

Index: Cabiddu, Salvatore; Contini, Liliana; Fattuoni, Claudia; Floris, Costantino; Gelli, Gioanna Tetrahedron, 1991 , vol. 47, # 44 p. 9279 - 9288

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Citation Number: 15

Abstract

Polylithiation reactions of 1, 3, 5-and 1, 2, 4-trimethoxybenzenes have been investigated. Results showed that it is possible to substitute all arylic hydrogens through one-pot sequential bimetalation/monometalation, monometalation/bimetalation or three monometalations. This reaction is strongly affected by steric hindrance.