Tetrahedron

Molecular design of glutathione-derived biochemical probes targeting the GS-X pump

K Furuta, K Tomokiyo, MT Kuo, T Ishikawa, M Suzuki

Index: Furuta, Kyoji; Tomokiyo, Keiichiro; Tien Kuo; Ishikawa, Toshihisa; Suzuki, Masaaki Tetrahedron, 1999 , vol. 55, # 24 p. 7529 - 7540

Full Text: HTML

Citation Number: 16

Abstract

The syntheses of novel glutathione derivatives as photoaffinity and fluorescent biochemical probes for the GS-X pump are described. GIF-0017, an S-alkylated glutathione derivative with a benzophenone photophore, competitively inhibits the transport of leukotriene C4 by the GS-X pump with an IC50 value of 0.40 μM, indicating the existence of strong interaction between the probe molecule and the GS-X pump.

Related Articles:

Microwave accelerated facile synthesis of fused polynuclear hydrocarbons in dry media by intramolecular Friedel–Crafts alkylation

[Kurteva, Vanya B.; Santos, Antonio Gil; Afonso, Carlos A.M. Organic and Biomolecular Chemistry, 2004 , vol. 2, # 4 p. 514 - 523]

More Articles...