Tetrahedron letters

A convenient procedure for the regioselective monoprotection of 1, n-diols

M Takasu, Y Naruse, H Yamamoto

Index: Takasu, Mayumi; Naruse, Yuji; Yamamoto, Hisashi Tetrahedron Letters, 1988 , vol. 29, # 16 p. 1947 - 1950

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Citation Number: 50

Abstract

A method is described for regioselective monoprotection of 1,n-diols. The new process depends on regioselective cleavage of orthoester, which is prepared from 1,n-diols and trialkylorthoesters. The produced mono-acetal is useful in subsequent steps as a normal acetal type protecting group. ... A new process of monoprotection of diols: The method depends on regioselective cleavage of orthoester, which is prepared in situ from 1,n-diols and ...