Design, synthesis, and biological evaluation of new 3-hydroxy-2-oxo-3-trifluoromethylindole as potential HIV-1 reverse transcriptase inhibitors

N Boechat, WB Kover, MM Bastos, NC Romeiro…

Index: Boechat, Nubia; Kover, Warner B.; Bastos, Monica M.; Romeiro, Nelilma C.; Silva, Alessa S. C.; Santos, Fernanda C.; Valverde, Alessandra L.; Azevedo, Maria L. G.; Wollinger, Wagner; Souza, Thiago M. L.; De Souza, Silmara Lucia Oliveira; De Frugulhetti, Izabel Christina P. P. Medicinal Chemistry Research, 2007 , vol. 15, # 9 p. 492 - 510

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Citation Number: 8

Abstract

Abstract The trifluoromethyl group (CF 3) is present in commercially available drugs of various therapeutic classes owing to its ability to modify and frequently improve their biological activities. Efavirenz is a trifluoromethylated inhibitor of human immunodeficiency virus type 1 (HIV-1) reverse transcriptase (RT) that shows good results in anti-HIV chemotherapy. With the objective of developing efficient non-nucleoside compounds, we ...