Biological activity evaluation and structure–activity relationships analysis of ferulic acid and caffeic acid derivatives for anticancer

…, Y Tang, B Li, L Liu, X Zhang, H Fu, J Duan

Index: Li, Weixia; Li, Nianguang; Tang, Yuping; Li, Baoquan; Liu, Li; Zhang, Xu; Fu, Haian; Duan, Jin-Ao Bioorganic and Medicinal Chemistry Letters, 2012 , vol. 22, # 19 p. 6085 - 6088

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Citation Number: 23

Abstract

The anticancer activities of alkyl esters and NO-donors of ferulic acid (FA) and caffeic acid (CA) were assessed by a high-throughout screening (HTS) method, and the structure– activity relationships were described. CA alkyl esters had better anticancer activities than FA alkyl esters with the same alkyl substituent. Mono-nitrates and phenylfuroxan nitrates were more potent than the dual nitrates. Phenylsulfonylfuroxan nitrates of FA, especially ...