Chemical Communications

Polyfunctional benzylic zinc chlorides by the direct insertion of magnesium into benzylic chlorides in the presence of LiCl and ZnCl 2

A Metzger, FM Piller, P Knochel

Index: Metzger, Albrecht; Piller, Fabian M.; Knochel, Paul Chemical Communications, 2008 , # 44 p. 5824 - 5826

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Citation Number: 58

Abstract

Polyfunctional organometallics are key intermediates for synthetic organic chemistry. 1 Organozinc compounds play an especially important role since they combine high reactivity with excellent functional group tolerance. 2 Benzylic zinc reagents are of particular interest since, in contrast to benzylic lithium 3 and magnesium 4 reagents, they tolerate numerous functional groups. 5 Recently, we have reported that LiCl considerably facilitates the insertion of metals (zinc, ...