Decorporation of aged americium deposits by oral administration of lipophilic polyamino carboxylic acids

FW Bruenger, G Kuswik-Rabiega…

Index: Bruenger, Fred W.; Kuswik-Rabiega, Gabriela; Miller, Scott C. Journal of Medicinal Chemistry, 1992 , vol. 35, # 1 p. 112 - 118

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Citation Number: 21

Abstract

Several new powerful chelating agents, suitable for the removal of a variety of certain heavy- metal ions from the body by oral application, have been synthesized and tested. Structurally, these compounds are partially lipophilic polyamino carboxylic acids (PACA). They were synthesized in nonaqueous media from triethylenetetramine (TI') by monoalkylation of a primary amino group, followed by exhaustive carboxymethylation of the remaining amino ...