A catalytic asymmetric synthesis of α-methylene lactones by the palladium-catalysed carbonylation of prochiral alkenyl halides

T Suzuki, Y Uozumi, M Shibasaki

Index: Suzuki, Takeyuki; Uozumi, Yasuhiro; Shibasaki, Masakatsu Journal of the Chemical Society, Chemical Communications, 1991 , # 22 p. 1593 - 1595

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Abstract

A catalytic asymmetric synthesis of the a-methylene lactones starting with the prochiral alkenyl halides 8 and 19 has been achieved for the first time, giving 9 in 57% enantiomeric excess (erne.) and 20 in 39% ee, respectively. ... Metal complex catalysed carbonylation reactions offer useful methods for the syntheses of carboxylic acids, esters, amides, aldehydes etc., and these methods are of considerable industrial value. However, application of a carbonylation ...