An artificial aspartic proteinase system

L Jiang, Z Liu, Z Liang, Y Gao

Index: Jiang, Lin; Liu, Zhilian; Liang, Zhi; Gao, Yunhua Bioorganic and Medicinal Chemistry, 2005 , vol. 13, # 11 p. 3673 - 3680

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Citation Number: 12

Abstract

A series of aza crown ether derivatives with or without carboxyl groups in their side arms were synthesized and the former showed deacylation activities toward amino acid p- nitrophenyl ester hydrohalides. Substrate-selective phenomena were also observed. The relationship between the structures and deacylation activities of corresponding compounds suggested a nucleophilic catalytic mechanism. The results partially simulate some ...