Synthesis of fully-substituted alkenylimidazoles from N-(cyanoalkyl) amides via the In-mediated allylation of nitrile and dehydrative cyclization cascade

YM Kim, S Lee, SH Kim, KH Kim, JN Kim

Index: Kim, Yu Mi; Lee, Sangku; Kim, Sung Hwan; Kim, Ko Hoon; Kim, Jae Nyoung Tetrahedron Letters, 2010 , vol. 51, # 45 p. 5922 - 5926

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Citation Number: 7

Abstract

Imidazole derivatives are important constituents in many biologically active substances and provide a scaffold for designing drugs, and many functional organic materials. 1 Numerous synthetic methodologies of imidazoles are available; however, they suffer from many drawbacks such as harsh reaction conditions and multistep synthesis. 2 and 3 Especially the synthesis of imidazoles having a C-alkenyl moiety required an indirect method; a sequential regio-controlled ...