Synthesis and biological evaluation of novel aliphatic amido-quaternary ammonium salts for anticancer chemotherapy: Part II

…, B Kim, BK Kim, SK Park, M Won, K Lee, K Lee…

Index: Yang, Jee Sun; Song, Doona; Ko, Won Jin; Kim, Bunyea; Kim, Bo-Kyung; Park, Song-Kyu; Won, Misun; Lee, Kiho; Lee, Kyeong; Kim, Hwan Mook; Han, Gyoonhee European Journal of Medicinal Chemistry, 2013 , vol. 63, p. 621 - 628

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Citation Number: 4

Abstract

A series of novel aliphatic amido-quaternary ammonium salts were synthesized and evaluated for their anticancer effects involving induction of RhoB. Most of these compounds, featuring open-ring forms of aliphatic amido-quaternary ammonium salts, exhibited potent anti-proliferative activities in human cancer cell lines, including PC-3, NUGC-3, MDA-MB- 231, ACHN, HCT-15, and NCI-H23. In further evaluation, the representative compound N, ...