Design, synthesis and evaluation of chalcone derivatives as anti-inflammatory, antioxidant and antiulcer agents

AN Choudhary, A Kumar…

Index: Choudhary, Alka N.; Kumar, Arun; Juyal, Vijay Letters in Drug Design and Discovery, 2012 , vol. 9, # 5 p. 479 - 488

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Citation Number: 7

Abstract

In the present study, a series of chalcone derivatives were designed based on QSAR analysis. The designed compounds were synthesized by Claisen Schmidt condensation and evaluated for anti-inflammatory, antioxidant and antiulcer activities. The results of the best 2D & 3D QSAR models suggested that by introducing electron releasing groups at R2 and introducing heteroatom with increasing bulkiness at R4 in the benzylideneacetophenone ...