Reaction of 5-Substituted tetrazoles with trifluoroacetic anhydride

LI Vereshchagin, ON Verkhozina, FA Pokatilov…

Index: Vereshchagin; Verkhozina; Pokatilov; Strunevich; Proidakov; Kizhnyaev Russian Journal of Organic Chemistry, 2007 , vol. 43, # 11 p. 1710 - 1714

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Citation Number: 7

Abstract

Abstract 5-Substituted tetrazoles readily react with trifluoroacetic anhydride at 20–25° C to give the corresponding 2-substituted 5-trifluoromethyl-1, 3, 4-oxadiazoles, in contrast to published data according to which the title compounds are converted into 1, 3, 4-oxadiazole derivatives on heating with carboxylic acid anhydrides or chlorides at 100–120° C. The reaction is governed not only by the rate of acylation of the tetrazole ring and temperature ...