A concise enantioselective synthesis of a fully oxygen substituted ring A taxol precursor

O Roy, G Pattenden, DC Pryde, C Wilson

Index: Roy, Olivier; Pattenden, Gerald; Pryde, David C.; Wilson, Claire Tetrahedron, 2003 , vol. 59, # 27 p. 5115 - 5121

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Citation Number: 16

Abstract

A concise synthesis of the oxygen substituted ring A compound 2 found in Taxol® 1a and Taxotere® 1b starting from 2, 2-dimethylcyclohexane-1, 3-dione and proceeding via the key intermediates 8 and 11, is described. The absolute configuration of 2 was established from an X-ray crystal structure determination of a 4-bromophenylbenzoate derivative, viz. 15.