Design and synthesis of tubulin ligands based on epothilones: a preliminary study

…, E Raimbaud, P Bertrand, D Quintard, P Renard…

Index: Vielle, Sophie; Raimbaud, Eric; Bertrand, Philippe; Quintard, Delphine; Renard, Pierre; Pfeiffer, Bruno; Gesson, Jean-Pierre Tetrahedron Letters, 2002 , vol. 43, # 50 p. 9213 - 9216

Full Text: HTML

Citation Number: 2

Abstract

Starting from the X-ray structure of epothilone B, an original, non macrocyclic, structure has been designed to mimic the key structural features of this potent anticancer agent; the preparation of a key intermediate incorporating four stereogenic centers is described from cyclohexane-1, 3-dione.