Tetrahedron letters

A new protecting group for the exocyclic amino groups of nucleosides

CVNS Varaprasad, F Johnson

Index: Varaprasad, Chamakura V.N.S.; Johnson, Francis Tetrahedron Letters, 2005 , vol. 46, # 12 p. 2163 - 2165

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Citation Number: 2

Abstract

Currently modified synthetic DNA, required for DNA damage and mutagenic studies 1 is obtained essentially in one of two ways, either by a presynthetic or a postsynthetic strategy. Nevertheless, at present, most modified DNA is prepared by the former method in which the modified base is pre-synthesized in a protected form 2 and then introduced into the oligomeric chain either by solution-based methods or by an automated resin-based procedure. 3 In a few ...