Journal of the American Chemical Society

Through-space polar-. pi. effects on the acidity and hydrogen-bonding capacity of carboxylic acids

CT Chen, JS Siegel

Index: Chen, Chao-Tsen; Siegel, Jay S. Journal of the American Chemical Society, 1994 , vol. 116, # 13 p. 5959 - 5960

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Citation Number: 61

Abstract

Acidity and hydrogen bonding capacity are crucial factors in molecular recognition1 and biocatalysk2 The ability to design and create biomimetic catalysts depends on an understanding of the way these properties change as a function of environment. Environmental control of functional group reactivity is a principal mechanism by which the chemistry of active site residues is modified. 3 Given that the interaction between two ...