Tetrahedron letters

A facile preparation of 2, 4-disubstituted furans

JA Nieman, BA Keay

Index: Nieman, James A.; Keay, Brian A. Tetrahedron Letters, 1994 , vol. 35, # 30 p. 5335 - 5338

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Citation Number: 8

Abstract

Abstract Treatment of 2-(tert-butyldimethylsilyl)-3-(triethylsilyloxymethyl) furan with 1.3 equiv. of n-BuLi (THF,− 40, 3h), followed by the addition of a variety of electrophiles provided 2, 3, 5- trisubstituted furans, which upon treatment with tetra-n-butylammonium fluoride afforded 2, 4- disubstituted furans in moderate to excellent yields.