Enzymatic syntheses of N-lauroyl-β-alanine homologs in organic media

T Izumi, Y Yagimuma, M Haga

Index: Izumi; Yagimuma; Haga JAOCS, Journal of the American Oil Chemists' Society, 1997 , vol. 74, # 7 p. 875 - 878

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Citation Number: 14

Abstract

Abstract Enyzmatic amidation of the primary amines β-alanine ethyl ester and 3- aminopropionitrile with methyl laurate by means of immobilized lipase (Candida antarctica lipase, CAL) resulted in the formation in good yield of N-lauroyl-β-alanine ethyl ester and 3- (N-lauroylamino)-propionitrile, respectively. When 3-amino-propionitrile was used as substrate, diisopropyl ether was a suitable solvent. Changing the reaction temperature (12 ...