Synthesis of functionalized acetophenones as protein tyrosine phosphatase 1B inhibitors

M Dixit, BK Tripathi, AK Srivastava, A Goel

Index: Dixit, Manish; Tripathi, Brajendra K.; Srivastava, Arvind K.; Goel, Atul Bioorganic and Medicinal Chemistry Letters, 2005 , vol. 15, # 14 p. 3394 - 3397

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Citation Number: 13

Abstract

Protein tyrosine phosphatase 1B (PTP1B) is an enzyme that plays a critical role in down- regulating insulin signaling through dephosphorylation of the insulin receptor. Studies have shown that PTP1B knock-out mice showed increased insulin sensitivity in muscle and liver as well as resistance to obesity. A series of functionalized acetophenones were synthesized and evaluated for their PTP1B inhibitory activity. Some of the screened compounds ...