Stereoselective Solid??Phase Synthesis of Chiral Piperidine Derivatives by Using an Immobilized Galactose Auxiliary

G Zech, H Kunz

Index: Zech, Gernot; Kunz, Horst Angewandte Chemie - International Edition, 2003 , vol. 42, # 7 p. 787 - 790

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Citation Number: 23

Abstract

Drug development [1] has significantly been accelerated by exploiting combinatorial solid- phase synthetic methodologies.[2] Although enantiomerically pure compounds [3] are of major interest for the pharmaceutical industry only few stereoselective syntheses on the solid-phase have been reported so far. Besides polymer-bound chiral ligands and catalysts [4] some immobilized chiral auxiliaries and their application in aldol condensations,[5] ...