Substituted 3-amino-1, 1-diaryl-2-propanols as potential antidepressant agents

JA Clark, MSG Clark, DV Gardner…

Index: Clark,J.A. et al. Journal of Medicinal Chemistry, 1979 , vol. 22, p. 1373 - 1379

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Citation Number: 6

Abstract

Other modifications of 1 were carried out. Analogues in which one of the phenyl groups was replaced by benzyl (36), phenethyl (37), 2-thienyl (38), or cyclohexyl (39a, b) were prepared by one of the methods already described. The 1-hydroxylated (40 and 42), 1-methoxylated (41), and ester (43 and 44) analogues were prepared by literature'methods. Two analogues containing a methyl or phenyl group at position 2 were prepared either by reduction of the ...