Tetrahedron letters

Photolabile linker for the solid-phase synthesis of base-sensitive oligonucleotides

C Dell'Aquila, JL Imbach, B Rayner

Index: Dell'Aquila, Christelle; Imbach, Jean-Louis; Rayner, Bernard Tetrahedron Letters, 1997 , vol. 38, # 30 p. 5289 - 5292

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Citation Number: 47

Abstract

o-Nitrophenyl-1, 3-propanediol was covalently linked to long chain alkyl amine controlled pore glass (LCAA-CPG) beads through a stable phosphoramidate diester link. The resulting solid support was found suitable for the automated synthesis of 3′-phosphate unmodified ...