Tetrahedron letters

A simple method for N-acylation of adenosine and cytidine nucleosides using carboxylic acids activated In-Situ with carbonyldiimidazole

ND Sinha, P Davis, LM Schultze, K Upadhya

Index: Sinha; Sinha, Nanda D.; Davis; Davis, Peter; Schultze; Schultze, Lisa M.; Upadhya; Upadhya, Krishna Tetrahedron Letters, 1995 , vol. 36, # 51 p. 9277 - 9280

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Citation Number: 11

Abstract

Carboxylic acids are activated with 1.1′-carbonyldiimidazole in acetonitrile to form N- acylimidazoles which are then treated with per-trimethylsilyl ethers of nucleosides adenosine or cytidine at ambient temperature to generate exclusively N-acylated-Adenosine or N-acylated-Cytidine derivatives.

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