Synthesis of pyridazine acetic acid derivatives possessing aldose reductase inhibitory activity and antioxidant properties

…, JY Boire, E Duroux, P Bastide, J Couquelet

Index: Coudert; Albuisson; Boire; Duroux; Bastide; Couquelet European Journal of Medicinal Chemistry, 1994 , vol. 29, # 6 p. 471 - 477

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Citation Number: 25

Abstract

Abstract N-Acetic acid derivatives of 4-carboxy-6-arylpyridazin-3-ones were synthesized for the dual purpose of inhibiting aldose reductase and exhibiting antioxidant properties. All the prepared compounds showed a significant in vitro aldose reductase inhibitory effect (10− 5 M≤ IC 50≤ 10− 4 M). The spatial configuration of the most active derivative 4f (4-i-PrC 6 H 4 at C 6, IC 50= 0 95× 10− 5 M) was compared with pharmacophore requirements of the ...