Biosynthesis of boldine (1, 10-dimethoxy-6aα-aporphine-2, 9-diol)

DS Bhakuni, S Tewari, RS Kapil

Index: Bhakuni; Tewari; Kapil Journal of the Chemical Society. Perkin transactions 1, 1977 , # 6 p. 706 - 709

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Citation Number: 13

Abstract

The incorporation of (±)-norprotosinomenine,(±)-nororientaline,(±)-nor-reticuline, and (±)- reticuline into boldine in Litsea glutinosa has been studied, and the specific utilization of the (±)-reticuline demonstrated. The evidence supports the direct oxidative coupling of (+)- reticuline to give isoboldine, which in turn is shown to be a specific precursor of boldine. The plants also converted norboldine into boldine. Double labelling experiments involving the ...