Novel 2-aminotetralin and 3-aminochroman derivatives as selective serotonin 5-HT7 receptor agonists and antagonists

…, R Leideborg, P Caldirola, P Zlatoidsky…

Index: Holmberg, Paer; Sohn, Daniel; Leideborg, Robert; Caldirola, Patrizia; Zlatoidsky, Pavel; Hanson, Sverker; Mohell, Nina; Rosqvist, Susanne; Nordvall, Gunnar; Johansson, Anette M.; Johansson, Rolf Journal of Medicinal Chemistry, 2004 , vol. 47, # 16 p. 3927 - 3930

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Citation Number: 50

Abstract

The understanding of the physiological role of the G-protein coupled serotonin 5-HT7 receptor is largely rudimentary. Therefore, selective and potent pharmacological tools will add to the understanding of serotonergic effects mediated through this receptor. In this report, we describe two compound classes, chromans and tetralins, encompassing compounds with nanomolar affinity for the 5-HT7 receptor and with good selectivity. Within ...

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