Isolation of intermediates in the rearrangement of 4-cyano-4, 5-dihydroazepines to furo [2, 3-b] pyridine derivatives

B Gregory, E Bullock, TS Chen

Index: Gregory; Bullock; Chen Canadian Journal of Chemistry, 1977 , vol. 55, # 23 p. 4061 - 4065

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Citation Number: 3

Abstract

4-Cyano-4, 5-dihydroazepines, when treated with an acidic ion-exchange resin in aqueous alcohol, undergo hydrolytic cleavage to a cyanooctanedionediester. The cyanooctanedione- diester and its thermal cyclization product, a 4, 7-dihydrofuro [2, 3-b] pyridine, are shown to