Investigation of diastereoselective tandem ring closing metathesis reactions toward the synthesis of functionalised spirocyclic piperidines
RAJ Wybrow, NG Stevenson, JPA Harrity
Index: Wybrow, Robert A. J.; Stevenson, Neil G.; Harrity, Joseph P. A. Synlett, 2004 , # 1 p. 140 - 142
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Citation Number: 14
Abstract
Abstract The stereoselective synthesis of a spiropiperidine through a diastereoselective tandem ring closing metathesis (RCM) reaction is reported. The efficient relay of stereochemistry from a pentyl chain to the newly formed spirocentre three carbon atoms away was found to be particularly dependant on the nature of the Ru-catalyst employed-1st generation Grubbs catalyst was found to be significantly more selective than the more ...
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[Wybrow, Robert A.J.; Edwards, Andrew S.; Stevenson, Neil G.; Adams, Harry; Johnstone, Craig; Harrity, Joseph P.A. Tetrahedron, 2004 , vol. 60, # 40 p. 8869 - 8880]
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