Reactive Esters in Amide Ligation with β??Hydroxyamines

…, F Zhang, S Ambadi, TR Ibarra??Rivera

Index: Pirrung, Michael C.; Zhang, Fa; Ambadi, Sudhakar; Ibarra-Rivera, Tannya R. European Journal of Organic Chemistry, 2012 , # 23 p. 4283 - 4286

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Citation Number: 4

Abstract

Abstract Amide formation between mildly activated esters and 1, 2-amino alcohols occurs without the need for coupling reagents. The reaction pathway involves facile intermolecular transesterification and intramolecular O [RIGHTWARDS ARROW] N transacylation. The ...