Il Farmaco

2-Pyrrolidinone moiety is not critical for the cognition-enhancing activity of piracetam-like drugs

S Scapecchi, C Martelli, C Ghelardini, L Guandalini…

Index: Scapecchi, Serena; Martelli, Cecilia; Ghelardini, Carla; Guandalini, Luca; Martini, Elisabetta; Gualtieri, Fulvio Farmaco, 2003 , vol. 58, # 9 p. 715 - 722

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Citation Number: 8

Abstract

Following the indications of previous work, 2-pyrrolidinone moiety of piracetam and piracetam-like compounds has been opened to the corresponding amide derivatives. As found previously in the case of 1, 4-diazabicyclo [4.3. 0] nonan-9-one compounds, the cognition-enhancing activity of 2-pyrrolidinone compounds is maintained in most cases, suggesting that this moiety is not crucial for activity.