New pyrazolo [3, 4-d] pyrimidines endowed with A431 antiproliferative activity and inhibitory properties of Src phosphorylation

S Schenone, O Bruno, A Ranise, F Bondavalli…

Index: Schenone; Bruno; Ranise; Bondavalli; Brullo; Fossa; Mosti; Menozzi; Carraro; Naldini; Bernini; Manetti; Botta Bioorganic and Medicinal Chemistry Letters, 2004 , vol. 14, # 10 p. 2511 - 2517

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Citation Number: 78

Abstract

New 4-aminopyrazolo [3, 4-d] pyrimidines bearing various substituents at the position 1 and 6, were synthesized. The new compounds showed antiproliferative activity toward A431 cells, were found to be inhibitors of Src phosphorylation, and induced apoptotic cell death. In particular, 2h was a better inhibitor of Src phosphorylation than the reference compound PP2.