8-Amino-3-benzyl-1, 2, 4-triazolo [4, 3-a] pyrazines. Synthesis and anticonvulsant activity.

…, DD Bankston, CJ Burchall, FE Soroko…

Index: Kelley, James L.; Linn, James A.; Bankston, Donald D.; Burchall, Christopher J.; Soroko, Francis E.; Cooper, Barrett R. Journal of Medicinal Chemistry, 1995 , vol. 38, # 18 p. 3676 - 3679

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Citation Number: 26

Abstract

for anticonvulsant activity against maximal electroshock-induced seizures (MES) in rats. The compounds were prepared in four stages from the phenylacetonitriles I. The intermediate (2, 2, 2-triethoxyethyl) benzenes 111 were condensed with 2-chloro-3-hydrazinopyrazine (IV) to provide the 3-benzyl-8-chloro-l, 2, 4-triazolo [4, 3alpyrazines V. The latter were converted to the 8-amine targets VI with methylamine or ammonia. Several compounds exhibited ...