Journal of Fluorine Chemistry
Synthesis of norfloxacin analogues catalyzed by Lewis and Brönsted acids: An alternative pathway
S Leyva, H Hernandez
Index: Leyva, Socorro; Hernandez, Hiram Journal of Fluorine Chemistry, 2010 , vol. 131, # 10 p. 982 - 988
Full Text: HTML
Citation Number: 7
Abstract
An alternative synthetic pathway to prepare norfloxacin analogues is presented. Three Lewis acids (CeCl3· 7H2O, AlCl3· 6H2O, ZnCl2) and one Brönsted acid (TsOH) were tested as catalysts in the preparation of 3, 4-difluoroacrylate. Cyclization of this acrylate at 55° C was achieved with the use of Eaton's reagent (P2O5/MeSO3H) a known Brönsted acid. The fluoroquinolone–boron complex presented high yields on C-7 nucleophilic substitution of ...