The Journal of Organic Chemistry

The Reaction of Unsaturated Acid Chlorides with Substituted Thioureas

CG Overberger, HA Friedman

Index: Overberger,C.G.; Friedman,H.A. Journal of Organic Chemistry, 1964 , vol. 29, p. 1720 - 1723

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Citation Number: 7

Abstract

The reaction of thioureas with acyl chlorides to yield N-acylthioureas has been rep~ rted~-~; the initial product, an S-acylisothiuronium chloride, undergoes rearrangement to the N- substituted compound upon heating, with the evolution of hydrogen chloride. In addition to reactions with alkylating or acylating agents, thiourea has also been shown to be capable of addition to an activated double bond, in the presence of an acid. Thus, addition has been ...