Tetrahedron letters

A new chiral dipyridylphosphine ligand Xyl-P-Phos and its application in the Ru-catalyzed asymmetric hydrogenation of β-ketoesters

…, H Chen, WH Kwok, KH Lam, ZY Zhou, CH Yeung…

Index: Wu, Jing; Chen, Hua; Kwok, Wai Him; Lam, Kim Hung; Zhou, Zhong Yuan; Yeung, Chi Hung; Chan, Albert S.C Tetrahedron Letters, 2002 , vol. 43, # 8 p. 1539 - 1543

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Citation Number: 81

Abstract

A new chiral dipyridylphosphine ligand Xyl-P-Phos has been synthesized and the structure of (S)-Xyl-P-Phos oxide has been characterized by single crystal X-ray diffraction. The ruthenium complex of this ligand, Ru (R-Xyl-P-Phos)(C6H6) Cl2, has been found to be a highly active, enantioselective and air-stable catalyst for the asymmetric hydrogenation of β- ketoesters and shows good potential for industrial applications.

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