Bioorganic & medicinal chemistry letters

Inhibition of monoamine oxidase by 3, 4-dihydro-2 (1H)-quinolinone derivatives

L Meiring, JP Petzer, A Petzer

Index: Meiring, Letitia; Petzer, Jacobus P.; Petzer, Anel Bioorganic and Medicinal Chemistry Letters, 2013 , vol. 23, # 20 p. 5498 - 5502

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Citation Number: 11

Abstract

Abstract In the present study, a series of 3, 4-dihydro-2 (1H)-quinolinone derivatives were synthesized and evaluated as inhibitors of recombinant human monoamine oxidase (MAO) A and B. The 3, 4-dihydro-2 (1H)-quinolinone derivatives are structurally related to a series of coumarin (1-benzopyran-2-one) derivatives which have been reported to act as MAO-B inhibitors. The results document that the quinolinones are highly potent and selective ...

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