A general and highly selective chelate-controlled intermolecular oxidative Heck reaction

JH Delcamp, AP Brucks, MC White

Index: Delcamp, Jared H.; Brucks, Alexandria P.; White, M. Christina Journal of the American Chemical Society, 2008 , vol. 130, # 34 p. 11270 - 11271

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Citation Number: 131

Abstract

A novel chelate-controlled intermolecular oxidative Heck reaction is reported that proceeds with a wide range of nonresonance stabilized α-olefin substrates and organoboron reagents to afford internal olefin products in good yields and outstanding regio-and E: Z stereoselectivities. Pd− H isomerization, common in many Heck reactions, is not observed under these mild, oxidative conditions. This is evidenced by outstanding E: Z selectivities ( ...