2-Benzazepines.[1, 2, 3] Triazolo [4, 5-d][2] benzazepines and dibenzo [c, f][1, 2, 3] triazolo [3, 4-a] azepines. Synthesis and evaluation as central nervous system …

EJ Trybulski, L Benjamin, S Vitone…

Index: Trybulski, E.J.; Benjamin, L.; Vitone, S.; Walser, A.; Fryer, R. Ian Journal of Medicinal Chemistry, 1983 , vol. 26, # 3 p. 367 - 372

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Citation Number: 19

Abstract

The facile synthesis of [1, 2, 3] triazolo [4, 5-d][2] benzazepines and dibenzo [c, fl [1, 2, 3] triazolo [3, 4-a] azepines by the addition of sodium azide to acetylenic benzophenones is described. Examination of the pharmacological data indicates that selected triazolobenzazepines are as potent as diazepam in the anti-pentylenetetrazole test and are weaker in the inclined screen and rotarod tests, suggesting that these compounds have ...