Study of the heterocyclization of vic??substituted hydrazides of acetylenylpyrazolecarboxylic acids into N??amino pyrazolopyridinones

SF Vasilevsky, EV Mshvidobadze…

Index: Vasilevsky, Sergei F.; Mshvidobadze, Elena V.; Elguero, Jose Journal of Heterocyclic Chemistry, 2002 , vol. 39, # 6 p. 1229 - 1233

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Citation Number: 18

Abstract

Abstract We report a new and efficient methodology to prepare N-amino pyrazolo [4, 3-c] pyridin-4-ones 4 and N-amino pyrazolo [3, 4-c] pyridin-4-ones 8 from vic- acetylenyl/hydrazido pyrazoles. The procedure involves the intermediate synthesis of methyl esters of acetylenyl-pyrazole carboxylic acids and the subsequent cyclization under a variety of conditions.