Enantioselective total synthesis of (R)-(−)-complanine

KAD Kamanos, JM Withey

Index: Kamanos, Krystal A.D.; Withey, Jonathan M. Beilstein Journal of Organic Chemistry, 2012 , vol. 8, p. 1695 - 1699

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Abstract

Abstract A route is described for the enantioselective synthesis of (R)-(−)-complanine, a marine natural product isolated from Eurythoe complanata, and known to be a causative agent in inflammation. An organocatalytic, asymmetric oxyamination of a homoconjugated all-Z-dienal intermediate provides versatile and efficient access to the natural product.