Organic letters

Pd-Catalyzed Arylation of Chlorotrifluoroethylene Using Arylboronic Acids

T Yamamoto, T Yamakawa

Index: Yamamoto, Tetsuya; Yamakawa, Tetsu Organic Letters, 2012 , vol. 14, # 13 p. 3454 - 3457

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Citation Number: 12

Abstract

When a mixture of CTFE, 2-naphthaleneboronic acid, PdCl 2 (dppf), and Na 2 CO 3 in 1,4-dioxane and H 2 O were heated at 100 °C for 2 h, 2-(1,2,2-trifluorovinyl)naphthalene was obtained in 78% isolated yield. Then, we examined the effect of the other base on this cross-coupling. The results are summarized in Table 1. When using K 2 CO 3 , the corresponding product 2a was obtained in a good yield (entry 3), but Li 2 CO 3 and Cs 2 CO 3 were not effective for the ...

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