A new preparation of 5-hydroxypyrimidines derived from carboxylic acids, epichlorohydrin, and ammonia

JW Hull Jr, K Otterson, D Rhubright

Index: Hull, John W.; Otterson, Kari; Rhubright, Douglas Journal of Organic Chemistry, 1993 , vol. 58, # 2 p. 520 - 522

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Citation Number: 4

Abstract

The preparation of high-value molecules from inexpensive and readily available starting materials with a minimal number of processing steps continues to be a critical challenge for industrial chemists. We recently reported2 an improved preparation of 2-tert-butylpyrimidine 1 from diamine 2a and pivalic acid using a simple vapor-phase catalytic reactor. Pyrimidine 1 is a precursor