Iron??Mediated Total Synthesis of 2, 7??Dioxygenated Carbazole Alkaloids

…, O Kataeva, AW Schmidt, HJ Knölker

Index: Krahl, Micha P.; Kataeva, Olga; Schmidt, Arndt W.; Knoelker, Hans-Joachim European Journal of Organic Chemistry, 2013 , # 1 p. 59 - 64

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Citation Number: 15

Abstract

Abstract We describe the efficient iron-mediated total synthesis of clausine O, clausine H (clauszoline-C) and anti-HIV active 7-methoxy-O-methylmukonal and clausine K (clauszoline-J). Consecutive C–C and C–N bond formations between 3-methoxy-4- methylaniline and a cyclohexadienyliumiron complex salt afforded 2, 7-dimethoxy-3- methylcarbazole, which served as common intermediate en route to the four alkaloids.