Simple and Practical Syntheses of Dibenzyl, Benzyl Ethyl and Benzyl Methyl Malonates

…, A Covarrubias-zúñiga, LA Maldonado

Index: Silva, Ana Luisa; Covarrubias-Zuniga, Adrian; Maldonado, Luis Angel Organic Preparations and Procedures International, 2000 , vol. 32, # 3 p. 272 - 275

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Abstract

The classical malonic ester synthesis is a widely used method to prepare homologous carboxylic acids andor esters from alkyl halides, but in some cases has the disadvantage of the strongly basic conditions required for the conversion of alkylated malonate to monocarboxylic acid. It is known that benzyl esters can release the corresponding carboxylic acids by hydrogenol ysis under essentially neutral conditions. Hence, a simple ...