Bulletin of the Chemical Society of Japan

Preparation of perfluoroalkyl ketones by the reaction of perfluoroalkyllithiums with esters.

H Uno, Y Shiraishi, H Suzuki

Index: Uno, Hidemitsu; Shiraishi, Yasukazu; Suzuki, Hitomi Bulletin of the Chemical Society of Japan, 1989 , vol. 62, # 8 p. 2636 - 2642

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Citation Number: 40

Abstract

A variety of esters react with perfluoroalkyllithiums in situ generated from perfluoroalkyl iodides and methyllithium to give perfluoroalkyl ketones in good yields. Perfluoroalkyllithiums add to α, β-unsaturated esters only in the 1, 2-addition mode even in the presence of copper salt. Exception was observed in the reaction with maleates where perfluoroalkylated succinic esters and normal 1, 2-addition products are obtained in ...

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