Nickel-catalyzed C–F bond activation and alkylation of polyfluoroaryl imines

X Yang, H Sun, S Zhang, X Li

Index: Yang, Xiuxiu; Sun, Hongjian; Zhang, Shumiao; Li, Xiaoyan Journal of Organometallic Chemistry, 2013 , vol. 723, p. 36 - 42

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Abstract

In this paper we show the C–F bond activation and alkylation in polyfluoroaryl imines. An active trimethylphosphine supported nickel-catalyzed cross-coupling reaction of polyfluoroaryl imines with ZnMe2 under mild conditions is described. According to the in situ19F NMR spectroscopic data, the substrates are quantitatively converted into di- methylation products, while mono-methylation can also be realized under the controlled ...