Factors controlling the diastereoface selectivity in the complementary asymmetric alkylation of α-alkyl β-keto esters

K Tomioka, K Ando, Y Takemasa, K Koga

Index: Tomioka, Kiyoshi; Ando, Kaori; Takemasa, Yutaka; Koga, Kenji Tetrahedron Letters, 1984 , vol. 25, # 49 p. 5677 - 5680

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Citation Number: 25

Abstract

Abstract Complementary asymmetric alkylation reaction of the lithioenamine derived from 2- methoxycarbonylcyclohexanone and (S)-valine tert-butyl ester was examined by employing the various electron pair donating additives in a toluene solvent, in order to clarify the factors controlling the diastereoface selectivity.